Calcitonin-like immunoreactivity in serum and tissues of the Bonnethead Shark, Sphyrna tiburo

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Nichols, S., Gelsleichter, J., Manire, C. A., & Cailliet, G. M. (2003). Calcitonin-like immunoreactivity in serum and tissues of the Bonnethead Shark, Sphyrna tiburo. Journal of Experimental Zoology Part A: Comparative Experimental Biology, 298(2), 150-161.
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TitleCalcitonin-like immunoreactivity in serum and tissues of the Bonnethead Shark, Sphyrna tiburo
AuthorsS. Nichols, J. Gelsleichter, C. Manire, G. Cailliet
AbstractCalcitonin is a 32-amino acid peptide hormone that is best known for its actions in maintaining skeletal integrity and calcium homeostasis in mammals. Calcitonin also appears to function in regulating certain aspects of animal reproduction, but the nature of this role remains unclear, particularly in nonmammalian vertebrates. The present study investigated the relationship between calcitonin and reproduction in the bonnethead shark (Sphyrna tiburo), a well-studied member of the oldest living vertebrate group (i.e. elasmobranchs) known to possess a calcitonin-producing organ. Serum calcitonin concentrations were measured in 28 reproductively mature female S. tiburo using a heterologous enzyme-linked immunosorbent assay (ELISA) system. Sites of calcitonin immunoreactivity were detected in tissues of mature female and embryonic S. tiburo using immunocytochemistry. Significant increases in serum calcitonin concentrations of mature female S. tiburo occurred during early stages of gestation, a period characterized by yolk-dependency of developing embryos. Immunoreactive calcitonin was detected in the duodenum and pancreas of embryonic S. tiburo sampled during the same period. The results from this study suggest that calcitonin obtained from endogenous and/or maternal sources may function in regulating yolk digestion in embryonic S. tiburo. Therefore, the association between calcitonin and reproduction in elasmobranchs may reflect an important role for this hormone in embryonic development. © 2003 Wiley-Liss, Inc.
JournalJournal of Experimental Zoology Part A: Comparative Experimental Biology
Date2003
Volume298
Issue2
Start page150
End page161
ISSN0022-104X
SubjectsAnimalia, Chondrichthyes, Elasmobranchii, Mammalia, Sphyrna tiburo, Sphyrnidae, Vertebrata, calcitonin, animal, animal embryo, article, breeding, enzyme linked immunosorbent assay, female, immunohistochemistry, metabolism, ovary follicle, physiology, pregnancy, prenatal development, reference value, reproduction, season, shark, Animals, Embryo, Nonmammalian, Enzyme-Linked Immunosorbent Assay, Ovarian Follicle, Pregnancy, Animal, Reference Values, Seasons, Sharks
NoteCited By (since 1996):5, Fish and Fisheries

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