Primitive synteny of vertebrate major histocompatibility complex class I and class II genes

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Ohta, Y., Okamura, K., McKinney, E. C., Bartl, S., Hashimoto, K., & Flajnik, M. F. (2000). Primitive synteny of vertebrate major histocompatibility complex class I and class II genes. Proceedings of the National Academy of Sciences of the United States of America, 97(9), 4712-4717. doi:10.1073/pnas.97.9.4712
Metadata
TitlePrimitive synteny of vertebrate major histocompatibility complex class I and class II genes
AuthorsY. Ohta, K. Okamura, C. McKinney, S. Bartl, K. Hashimoto, F. Flajnik
AbstractMajor histocompatibility complex (MHC) class I and class II molecules bind to and display peptidic antigens acquired from pathogens that are recognized by lymphocytes coordinating and executing adaptive immune responses. The two classes of MHC proteins have nearly identical tertiary structures and were derived from a common ancestor that probably existed not long before the emergence of the cartilaginous fish. Class I and class II genes are genetically linked in tetrapods but are not syntenic in teleost fish, a phylogenetic taxon derived from the oldest vertebrate ancestor examined to date. Cartilaginous fish (Sharks, skates, and rays) are in the oldest taxon of extant jawed vertebrates; we have carried out segregation analyses in two families of nurse sharks and one family of the banded houndshark that revealed a close linkage of class IIα and β genes both with each other and with the classical class I (class Ia) gene. These results strongly suggest that the primordial duplication giving rise to classical class I and class II occurred in cis, and the close linkage between these two classes of genes has been maintained for at least 460 million years in representatives of most vertebrate taxa.
JournalProceedings of the National Academy of Sciences of the United States of America
Date2000
Volume97
Issue9
Start page4712
End page4717
ISSN00278424
Subjectsmajor histocompatibility antigen class 1, major histocompatibility antigen class 2, antigen binding, article, fish, gene duplication, gene expression, major histocompatibility complex, priority journal, synteny, taxonomy, vertebrate, Amino Acid Sequence, Animals, Base Sequence, DNA Primers, Evolution, Female, Fishes, Gene Library, Genes, MHC Class I, Genes, MHC Class II, Haplotypes, Linkage (Genetics), Molecular Sequence Data, Polymerase Chain Reaction, Sequence Alignment, Sequence Homology, Amino Acid, Sharks, Vertebrates, Chondrichthyes, Ginglymostomatidae, Teleostei, Tetrapoda, Triakis scyllium, Vertebrata
NoteCited By (since 1996):82, CODEN: PNASA

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