Evidence for thyroid endocrine disruption in wild fish in San Francisco Bay, California, USA. Relationships to contaminant exposures

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Navdeep, K. B., Waggoner, C., Reyes, J. A., Fairey, R., & Kelley, K. M. (2010). Evidence for thyroid endocrine disruption in wild fish in San Francisco Bay, California, USA. Relationships to contaminant exposures. Aquatic Toxicology, 96(3), 203-215. doi:10.1016/j.aquatox.2009.10.023
TitleEvidence for thyroid endocrine disruption in wild fish in San Francisco Bay, California, USA. Relationships to contaminant exposures
AuthorsK. Navdeep, C. Waggoner, J. Reyes, R. Fairey, K. Kelley
AbstractIt is well documented that many coastal and estuarine environments adjacent to developed and industrialized urban centers, such as the San Francisco Bay Area, are significantly contaminated by anthropogenic chemicals. However, it is not well understood to what extent existing contaminants, many with continuing inflows into the environment, may impact exposed wildlife. This study provided an initial characterization of thyroid endocrine-related effects and their relationship to accumulated contaminants in two indigenous fish species sampled from different San Franicsco Bay Area study sites. Plasma concentrations of thyroxine (T4) were significantly reduced in fish sampled from highly impacted locations such as Oakland Inner Harbor and San Leandro Bay as compared with fish from other locations representing relatively lower human impact, including Bodega Bay, Redwood City and a remote site on Santa Catalina Island. Triiodothyronine (T3) levels also varied significantly by location, with differing T3/T4 ratios in fish from some locations suggestive of altered peripheral deiodinase activity. The changes in thyroid endocrine parameters were significantly correlated with hepatic concentrations of certain environmental contaminants. A large number of polychlorinated biphenyl (PCB) congeners, both co-planar (dioxin-like) and non-co-planar, exhibited significant inverse correlations with T4 levels in the fish, while in contrast, T3 and T3/T4 ratio were positively correlated with PCB exposures. The positive correlation between T3/T4 ratio and PCBs supports the hypothesis that environmental PCBs may alter T4 deiodination or turnover, actions of PCBs reported in laboratory experiments. Some relationships between chlorinated pesticides including DDT and chlordanes, but fewer relationships with PAHs, were also observed. Together, these findings indicate that the thyroid endocrine system is exhibiting alterations associated with different aquatic environments in the San Francisco Bay Area, which are significantly related to current-day exposures of the fish to contaminant chemicals such as PCBs. © 2009 Elsevier B.V. All rights reserved.
JournalAquatic Toxicology
Start page203
End page215
Subjectschlordane, chlorphenotane, liothyronine, pesticide, polychlorinated biphenyl derivative, polycyclic aromatic hydrocarbon, thyroxine, thyroxine deiodinase, anthropogenic effect, aquatic environment, chemical pollutant, coastal zone, DDT, endocrine disruptor, estuarine environment, fish, PAH, PCB, animal disease, animal tissue, article, bioaccumulation, chemical waste, concentration (parameters), contaminated fish, controlled study, deiodination, ecotoxicology, environmental exposure, environmental impact assessment, enzyme activity, female, liothyronine blood level, liver level, male, nonhuman, priority journal, thyroid disease, thyroxine blood level, United States, water contamination, wild animal, Animals, California, Endocrine Disruptors, Environmental Monitoring, Fishes, Liver, Thyroid Gland, Triiodothyronine, Water Pollutants, Chemical, San Francisco Bay
NoteFish and Fisheries, CODEN: AQTOD