Multidrug efflux transporters limit accumulation of inorganic, but not organic, mercury in sea urchin embryos

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Bošnjak, I., Uhlinger, K. R., Heim, W., Smital, T., Franekić-Čolić, J., Coale, K., … Hamdoun, A. (2009). Multidrug efflux transporters limit accumulation of inorganic, but not organic, mercury in sea urchin embryos. Environmental Science and Technology, 43(21), 8374-8380. doi:10.1021/es901677r
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TitleMultidrug efflux transporters limit accumulation of inorganic, but not organic, mercury in sea urchin embryos
AuthorsI. Bošnjak, R. Uhlinger, W. Heim, T. Smital, J. Franekić-Čolić, K. Coale, D. Epel, A. Hamdoun
AbstractMercuric compounds are persistent global pollutants that accumulate in marine organisms and in humans who consume them. While the chemical cycles and speciation of mercury intheoceansarerelativelywelldescribed, thecellularmechanisms that govern which forms of mercury accumulate in cells and why they persist are less understood. In this study we examined the role of multidrug efflux transport in the differential accumulation of inorganic (HgCl2) and organic (CH3HgCl) mercury inseaurchin (Strongylocentrotus purpuratus) embryos. We found that inhibition of MRP/ABCC-type transporters increases intracellular accumulation of inorganic mercury but had no effect on accumulation of organic mercury. Similarly, pharmacological inhibition of metal conjugating enzymes by ligands GST/GSH significantly increases this antimitotic potency of inorganic mercury, but had no effect on the potency of organic mercury. Our results point to MRP-mediated elimination of inorganic mercury conjugates as a cellular basis for differences in the accumulation and potency of the two major forms of mercury found in marine environments. © 2009 American Chemical Society.
JournalEnvironmental Science and Technology
Date2009
Volume43
Issue21
Start page8374
End page8380
ISSN0013936X
SubjectsGlobal pollutants, In-cell, Inorganic mercury, Intracellular accumulation, Marine environment, Marine organisms, Multidrug efflux, Organic mercury, Pharmacological inhibition, Sea urchin, Chemical speciation, Enzyme inhibition, Mammals, Marine biology, Marine pollution, Mercury compounds, Mercury (metal), glutathione, glutathione transferase, inorganic compound, mercury, organic compound, bioaccumulation, drug, echinoderm, embryo, food consumption, inhibition, ligand, mercury (element), speciation (chemistry), article, controlled study, marine mammal, mitosis, nonhuman, Animals, Biological Transport, Embryo, Nonmammalian, Environmental Monitoring, Inorganic Chemicals, Intracellular Space, Membrane Transport Proteins, Organic Chemicals, Sea Urchins, Echinoidea, Strongylocentrotus purpuratus
NoteCited By (since 1996):9, CODEN: ESTHA

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